Hormonal action is accomplished by the specific binding of hormones to one of two types of receptors:
| Membrane |
|
| Nuclear | Steroid type receptors derived from cholesterol. Are degraded as either
Include binding to:
|
Hormones can be:
- Natural
- Bio-engineered
- Modified derivatives
Binding of ligands to nuclear receptors promotes specific binding of the receptor complex to DNA regulatory elements that modulate rates of transcription.
The synthesis of proteins takes hours. Hormones can either increase or decrease protein synthesis.
Side effects of hormonal drugs have their basis in normal feedback mechanisms of hormonal action.
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Last updated October 2013
