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Dosing and Dose Equivalence of Metformin

Initial dose  Titration Maximum dose

Metformin (Glucophage) IR Tab

500 mg BID

500 mg Qweek

2550mg/day in 2 or 3 doses

Metformin (Glucophage) XR Tab

  850 mg QDay

850 mg Qweek

2550mg/day in 2 or 3 doses

Metformin (Riomet) IR solution

(100mg/mL)

500 mg BID

OR

  850 mg QDay

500 mg QWeek

OR

850 mg Q2weeks

OR

From 500mg BID to 850mg BID after 2weeks

2550mg/day in three divided doses.

Metformin (Fortamet) XR TAB

500 mg QDay

OR

1000 mg QDay

500 mg QWeek

2500mg/day

Metformin (Glumetza) XR

500 mg QDay

500 mg Qweek or Q2weeks

2000 mg/day

Metformin Generic (Avkare) XR Tab

500 mg QDay

500 mg Qweek

2000 mg/day

Metformin Generic (Amneal) XR Tab

500 mg QDay

500 mg Qweek

2000 mg/day

 

Last updated: 04/22/13 By: Christian Mbangha Muenyi

References:

Metformin. In: DRUGDEX (Internet Database). Ann Arbor, MI, Thomson Reuters (Healthcare) Inc.

Metformin Hydrochloride Extended release Tablets (Avkare) package insert. Pulaski, TN 38478.

Metformin Hydrochloride Extended release Tablets (Amneal) package insert. Glasgow, KY 42141.