Endocrinology Series: Stimulators Via Positive and Negative Regulation

Ever wondered which releasing factors stimulate the secretion of which respective hormone in the pituitary gland? Or what inhibits the secretion of hormones in the pituitary gland? This clinical chart provides the answer.

Stimulators Via Positive Regulation

Thyroid Releasing Hormone (TRH )	Thyroid Stimulating Hormone and Prolactin (TSH and PRl)
GNRH (Gonadotropin Releasing Hormone)	FSH and LH (Luteinizing and Follicle Stimulating Hormones)
CRH (Corticotropin Releasing Hormone)	ACTH and GHRH
GHRH	GH

 Inhibitors Via Negative Regulation 

Dopamine	PRl
Somatostatin (SRIF)	GH and TSH
Sex Steroids	FSH and LH

Somatostatin = SRIF = Somatotropin release inhibiting factor. It is synthesized in both the cell bodies of the brain and the pancreas. SOMATOTROPIN is the GH that is naturally produced in the body. Therefore, it makes sense that SRIF (somatostatin) inhibits growth hormone. SOMATROPIN is the generic name for all synthesized GH that is identical with human GH.

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Last updated October 2013