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Major Drug-Drug Interactions of Beta Blockers

Drug

Interaction

AMIODARONE Hypotension, bradycardia, or cardiac arrest.
DRONEDARONE Increased incidence of bradycardia.
VERAPAMIL Hypotension, bradycardia.
DILTIAZEM Increased risk of hypotension, bradycardia, AV conduction
CLONIDINE Increased risk of sinus bradycardia; exaggerated clonidine withdrawal response (acute hypertension)-with Acebutolol only
FINGOLIMOD Slowing of the heart rate or atrioventricular conduction, which may result in severe bradycardia or heart block-with Acebutolol only
BETA-2 AGONISTS severe bronchospasm and decreased effectiveness of the beta-2 agonist.
FENOLDOPAM exaggeration of hypotensive response

Last modified January 2014 by Christian M. Muenyi, Pharm.D., M.S.