| Drug Class | Drug | Dosing | Side Effect |
|
Alpha-Blockers |
– Prazosin (Minipres)
– Alfuzosin (Uroxatral)
– Doxazosin (Cardura)
– Tamsulosin (Flomax)
– Terazosin (Hytrin)
– Silodosin (Rapaflo) |
-initial, 0.5-1 mg PO HS-maintenance, 0.5-2 mg PO BID
10 mg PO QDay
IR: Initial: 1 mg PO QDay; titrate at 1-2 wk intervals Maintenance: 1-8 mg PO QDay XR: Initial: 4 mg PO QDay with breakfast; titrate at 3-4 wk intervals Maintenance: 4-8 mg PO QDay
0.4 mg PO QDay; if no response after 2 to 4 weeks, may increase to 0.8 mg
Initial: 1 mg PO QDay HS Maintenance: 1-10 mg PO QDay; MAX 20 mg/day
8 mg PO QDay with a meal |
– Orthostatic hypotension, Palpitations- Nausea
– Asthenia, Dizziness, Headache, Lethargy, Somnolence.
-Xerostomia – Dizziness, Vertigo – Fatigue, Malaise – Afib, Palpitations, Prolonged QT interval, Syncope
-Edema, Hypotension – Nausea – Dizziness, Headache, Somnolence, Vertigo – Intraoperative floppy iris syndrome – Priapism (rare) – Hepatitis – Angioedema
– Infectious disease – Backache – Asthenia, Dizziness, Headache, Insomnia, Somnolence – Abnormal ejaculation – Retinal detachment – Priapism
– Orthostatic hypotension, Palpitations, Peripheral edema – Nausea – Asthenia, Dizziness, Headache, Somnolence – Nasal congestion – Syncope – Intraoperative floppy iris syndrome – Priapism – Orthostatic hypotension – Diarrhea – Dizziness, Headache – Retrograde ejaculation – Nasal congestion, Nasopharyngitis |
| 5- Alpha-reductase inhibitors (5-ARIs) | – Finasteride (Proscar)
– Dutasteride (Avodart, Jalyn) |
5 mg PO QDay; alone or in combi w/ doxazosin
Monotherapy: 0.5 mg PO QDay Combination: 0.5 mg PO and tamsulosin 0.4 mg QDay |
– Abnormal ejaculation, Breast tenderness, Reduced libido– Neoplasm of male breast
– Prostate cancer, high-grade
-Disorder of breast, abnormal PSA – Disorder of ejaculation Impotence Reduced libido – Cutaneous hypersensitivity – Immune hypersensitivity reaction – Angioedema |
| Phosphodiesterase type 5 (PDE5) Inhibitor | Tadalafil (Cialis) | 5 mg PO QDay at the same time | – Flushing- Indigestion, Nausea
– Backache, Myalgia – Headache -Nasopharyngitis, Respiratory tract infection – Angina, Chest pain, Heart failure, Myocardial infarction, Tachycardia – Stevens-Johnson syndrome – Cerebral hemorrhage, Cerebrovascular accident, Seizure – Non-arteritic ischemic optic neuropathy, Retinal artery occlusion, Thrombosis of retinal vein – Decreased hearing, Sudden onset, Sudden hearing loss |
Benign Prostatic Hyperplasia: Treatment Options & Associated Side Effects
