Beta Blockers Adverse Effects

Beta Blockers Adverse Effects (AE)

Drug

Common AE

Serious AE

Acebutolol

(Sectral)

Atenolol (Tenormin)

Betaxolol (Betoptic S, Kerlone)

Bisoprolol (Zebeta)

Esmolol (Brevibloc)

Metoprolol

Succinate

(Toprol XL)

Tartrate (Lopressor)

Nebivolol (Bystolic)

Labetalol (Normodyne,Trandate)

Carvedilol (Coreg)

Nadolol (Corgard)

Pindolol (Visken)

Propranolol

(Inderal, Inderal LA, InnoPran XL, Propranolol HCl Intensol)

Sotalol (Betapace, Betapace AF, Sorine)

Timolol

(Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE Ocumeter, Blocadren, Istalol, Timoptic-XE Ocumeter Plus)

Penbutolol (Levatol)

• Dizziness (6% )
• Headache (6% )
• Fatigue (11% )

• Bradyarrhythmia (3% to 18% ), Cold extremities (12% ), Hypotension (4% to 25% )
• Dizziness (13% )
• Depression (up to 12% )
• Fatigue (up to 26% )

• Bradyarrhythmia (5.8% to 8.1% )
• Indigestion (3.9% to 4.7% ), Nausea (1.6% to 5.8% )
• Arthralgia (3.1% to 5.2% ), Chest pain (2.4% to 7.1% )
• Burning sensation in eye (30%, ophthalmic )
• Fatigue (2.9% to 9.7% )

• Diarrhea (2.6% to 3.5% )
• Headache (8.8% to 10.9% )
• Rhinitis (2.9% to 4% ), Upper respiratory infection (4.8% to 5% .)
• Fatigue (6.6% to 8.2%)

• Hypotension (20%-50% )
• Injection site pain (8% )
• Nausea (7% )

• Bradyarrhythmia (3%), Cold extremities (1%), Heart failure (1%), Hypotension (1%)
• Pruritus (5% ), Rash (5% )
• Constipation (1%), Diarrhea (5%), Indigestion (1%), Nausea (1%)
• Dizziness (10%), Fatigue (10%), Headache
• Depression (5%)
• Dyspnea (3%), Wheezing (1%)

• Bradyarrhythmia (3%-16%), Heart block (5%), Heart failure (27%), Hypotension (1%-27%)
• Pruritus (5%), Rash (5%)
• Constipation (1%), Diarrhea (5%), Indigestion (1%), Nausea (1%)
• Dizziness (10%), Fatigue (10%), Headache
• Depression (5%)
• Dyspnea (1%-3%), Wheezing (1%)

• Nausea (1% to 3% )
• Dizziness (2% to 4% ), Headache (6% to 9% ), Somnolence

• Orthostatic hypotension (1%, oral ; 58%, IV )
• Has tingling sensation (7% .)
• Nausea (14% )
• Dizziness (9% to 20% )
• Nasal congestion (3% )
• Fatigue (11% )

• Bradyarrhythmia (3% to 10% ), Hypotension (1.8% to 20.2% ), Peripheral edema (1% to 7% )
• Abnormal weight gain (10% to 12% ), Hyperglycemia (5% to 12% )
• Diarrhea (2% to 12% )
• Dizziness (6% to 33% )
• Erectile dysfunction (13.5% )
• Fatigue (24% )

• Bradyarrhythmia (2% )
• Dizziness (2% )
• Fatigue (2% )

• Edema (6% to 16% )
• Arthralgia (7% ), Myalgia (10% )
• Dizziness (9%), Feeling nervous (7% ), Insomnia (10%)
• Fatigue (8% )

• Dermatitis, Pruritus, Urticaria
• Dizziness (4% to 7% )
• Fatigue (5% to 7% )

• Bradyarrhythmia ( 12.3% to 16% ), Chest pain (2.5% to 16% ), Lightheadedness (12% ), Palpitations (14% )
• Rash (5% )
• Nausea (5.7% to 10% )
• Disturbance of consciousness (4% ), Dizziness ( 13.1% to 20% ), Headache (3.3% to 11.5% )
• Dyspnea (9.2% to 21% )
• Fatigue (18.9% to 20% )

• Angina, Bradyarrhythmia (5% to 9.1%, oral ), Heart failure (8%, oral), Hypotension
• Pruritus, Rash, Urticaria
• Abdominal pain, Diarrhea, Indigestion, Nausea, Vomiting
• Cramp
• Confusion (13%), Dizziness (2.3% to 6%, oral ), Headache (1.7%, oral ; 1% to 5%, ophthalmic)
• Blurred vision (33%, ophthalmic ), Burning sensation in eye (12.5%, ophthalmic ), Dry eyes
• Depression (9.2%, ophthalmic ), Hallucinations (11%), Psychotic disorder (3%)
• Cough, Dyspnea (1.7%, oral )
• Fatigue (3.4% to 5%, oral ), Infectious disease

• Nausea (4.3% )
• Dizziness (4.9% ), Headache (7.8% )
• Fatigue (4.4% )

• Angina (2% ), Bradyarrhythmia (2% ), Heart failure (2% )
• Hepatotoxicity (rare)
• Anaphylaxis, Systemic lupus erythematosus (rare .)

• Heart failure, Myocardial infarction, Ventricular arrhythmia
• Thyrotoxicosis
• Anaphylaxis, Systemic lupus erythematosus
• Pulmonary embolism (1.2% )
• Withdrawal sign or symptom

• Atrioventricular block, Myocardial infarction

• Heart block (less than 1% )
• Anaphylaxis
• Seizure (less than 1% )
• Bronchospasm (less than 1% ), Pulmonary edema (less than 1% )

• Bronchospasm (1%)

• Bronchospasm (1%)

• Angina, Myocardial infarction, Ventricular arrhythmia

• Heart failure
• Hyperkalemia
• Hepatotoxicity
• Bronchospasm

• Atrioventricular block (greater than 1% to 3% )
• Erythema multiforme, Stevens-Johnson syndrome, Toxic epidermal necrolysis
• Aplastic anemia
• Intraoperative floppy iris syndrome
• Asthma with status asthmaticus (rare )

• Atrioventricular block, Cardiac dysrhythmia (1% ), Heart failure (1% )

• Heart failure (less than 1% )

• Congestive heart failure, Heart block
• Erythema multiforme, Stevens-Johnson syndrome, Toxic epidermal necrolysis
• Anaphylaxis
• Asthma, Bronchospasm
• Withdrawal sign or symptom

• Congestive heart failure (1.2% to 3.3% ), Heart failure (5% ), Prolonged QT interval, Torsades de pointes (0.5% to 5.8% )
• Cerebrovascular accident (1% )

• Cardiac dysrhythmia (1%), Myocardial infarction (rare)
• Bronchospasm (0.6%, oral )

• Heart block (rare), Heart failure