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Benign Prostatic Hyperplasia: Treatment Options & Associated Side Effects

Drug Class Drug Dosing Side Effect



















– Prazosin (Minipres) 


– Alfuzosin (Uroxatral)





– Doxazosin (Cardura)











– Tamsulosin   (Flomax)






– Terazosin   (Hytrin)





– Silodosin (Rapaflo)

-initial, 0.5-1 mg PO HS-maintenance, 0.5-2 mg PO BID



10 mg PO QDay







Initial: 1 mg PO QDay; titrate at 1-2 wk intervals

Maintenance: 1-8 mg PO QDay


Initial: 4 mg PO QDay with breakfast; titrate at 3-4 wk   intervals

Maintenance: 4-8 mg PO QDay


0.4 mg PO QDay; if no response after 2 to 4 weeks, may   increase to 0.8 mg





Initial: 1 mg PO QDay HS

Maintenance: 1-10 mg PO QDay; MAX 20 mg/day




8 mg PO QDay with a meal

– Orthostatic   hypotension, Palpitations- Nausea

– Asthenia, Dizziness, Headache, Lethargy, Somnolence.



– Dizziness, Vertigo

– Fatigue, Malaise

– Afib, Palpitations, Prolonged QT interval, Syncope


-Edema, Hypotension

– Nausea

– Dizziness, Headache, Somnolence, Vertigo

– Intraoperative floppy iris syndrome

– Priapism (rare)

– Hepatitis

– Angioedema







– Infectious disease

– Backache

– Asthenia, Dizziness, Headache, Insomnia, Somnolence

– Abnormal ejaculation

– Retinal detachment

– Priapism


– Orthostatic hypotension, Palpitations, Peripheral edema

– Nausea

– Asthenia, Dizziness, Headache, Somnolence

– Nasal congestion

– Syncope

– Intraoperative floppy iris syndrome

– Priapism

– Orthostatic hypotension

– Diarrhea

– Dizziness, Headache

– Retrograde ejaculation

– Nasal congestion, Nasopharyngitis

5- Alpha-reductase inhibitors (5-ARIs) – Finasteride (Proscar) 



– Dutasteride (Avodart,   Jalyn)

5 mg PO QDay;  alone or   in combi w/ doxazosin 


Monotherapy: 0.5 mg PO QDay

Combination: 0.5 mg PO and tamsulosin 0.4 mg QDay

Abnormal ejaculation, Breast tenderness, Reduced libido– Neoplasm of male breast

– Prostate cancer, high-grade


-Disorder of breast, abnormal   PSA

– Disorder of ejaculation Impotence Reduced libido

– Cutaneous hypersensitivity

– Immune hypersensitivity reaction

– Angioedema

Phosphodiesterase   type 5 (PDE5) Inhibitor Tadalafil (Cialis) 5 mg PO QDay at the same time – Flushing- Indigestion, Nausea

– Backache, Myalgia

– Headache

-Nasopharyngitis, Respiratory tract infection

– Angina, Chest pain, Heart failure, Myocardial infarction,   Tachycardia

– Stevens-Johnson syndrome

– Cerebral hemorrhage, Cerebrovascular accident, Seizure

– Non-arteritic ischemic optic neuropathy, Retinal artery   occlusion, Thrombosis of retinal vein

– Decreased hearing, Sudden onset, Sudden hearing loss

Christian Muenyi, Pharm.D., M.S. (12 Posts)

Christian Muenyi is a research scientist. After obtaining his Masters of Science in Organic Chemistry, he developed novel extraction techniques that have yielded new discoveries in anti-oxidation and anti-microbial science. He obtained his Pharm.D. from the University of Tennessee Health Science Center.

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